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Any substance that was identified by NPSfinder was considered a CE if it was either described as having nootropic abilities by psychonauts or if it was listed among the known CEs by Froestl and colleagues

Pharmaceutics 14(1):94

Signaling pathways from Trk activation: PI3K/Akt pathway phosphorylates Bad (pro-apoptotic protein) preventing it from blocking Bcl-2 and Bcl-xL (anti-apoptotic proteins)